{"id":1927,"date":"2025-10-30T03:00:19","date_gmt":"2025-10-30T03:00:19","guid":{"rendered":"https:\/\/antoniosdougalis.com\/?p=1927"},"modified":"2025-10-30T03:02:52","modified_gmt":"2025-10-30T03:02:52","slug":"neural-networks-copy","status":"publish","type":"post","link":"https:\/\/antoniosdougalis.com\/?p=1927","title":{"rendered":"DOPAMINE NEURON"},"content":{"rendered":"\t\t
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#<\/span>Dopamine<\/a> Neuron degeneration in the midbrain is the cardinal event responsible for the loss of control over voluntary movement in #<\/span>Parkinson<\/a>‘s Disease, #<\/span>parkinsonsdisease<\/a>. #<\/span>parkinsonsresearch<\/a>
The importance of calcium channels and intracellular calcium overload during times of intense neuronal activation is though to play a central role in the unfolding of the early events behind Substantia Nigra pars compacta (SNc) neuronal death.

Below I present you with my published computational model of SNc neurons where we investigate the impact of different isoforms of calcium channels on the pacemaking activity and on NMDA induced bursting activity of SNc neurons (Ortner et al., 2017 J Neurosci).

We argue that dihydropyridine calcium channel blockers, like isradipine, have higher propensity in blocking arterial calcium currents (responsible for their relaxation properties and antihypertensive actions) but they perform much less robustly in controlling calcium overflux in SNc neurons during intense activity, at least at therapeutic plasma concentrations reported in humans.

Better strategies must be envisaged for the control of calcium dynamics in midbrain dopaminergic systems to account for the differential calcium influx and the consequent mitochondrial induced oxidative stress and neuronal death

Feel free download the model in order to simulate parameters that control calcium flux and the dynamics of the ionic conductances that control burst firing. Code runs in NEURON environment using precompiled .mod file in C!

Have fun simulating

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#Dopamine Neuron degeneration in the midbrain is the cardinal event responsible for the loss of control over voluntary movement in #Parkinson‘s Disease, #parkinsonsdisease. #parkinsonsresearchThe importance of calcium channels and intracellular calcium overload during times of intense neuronal activation is though to play a central role in the unfolding of the early events behind Substantia Nigra […]<\/p>\n","protected":false},"author":2,"featured_media":1934,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-1927","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","entry","has-media"],"_links":{"self":[{"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/posts\/1927","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1927"}],"version-history":[{"count":8,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/posts\/1927\/revisions"}],"predecessor-version":[{"id":1941,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/posts\/1927\/revisions\/1941"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=\/wp\/v2\/media\/1934"}],"wp:attachment":[{"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1927"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1927"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/antoniosdougalis.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1927"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}